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In a recent study in liver cirrhosis of any cause, not only urinary 51 Cr-EDTA excretion was elevated in about half the patients and associated with Child-Pugh state, it was also present in all ascites samples from patients with spontaneous bacterial peritonitis (SBP) (143)

[58] proposed a metabolic trap hypothesis that suggests ME/CFS patients suffer from insufficient kynurenine production due to gene mutations in IDO2 [58]

Yet, overproduction of reactive oxygen species (ROS), induced by environmental toxins, inflammation, or mitochondrial dysfunction, overwhelms the cellular antioxidant defense system, resulting in oxidative stress [27]

Archived from the original on April 15, 2021

10.1007/s00011-016-1004-4 316 ZhouT.WangY.LiuM.HuangY.ShiJ.DongN.et al (2020)