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The researchers also investigated the interaction of neurotransmitter systems and hypothalamic/pituitary hormones through the pharmacological depletion of the respective neurotransmitters (Ross et al., 1973) and leads to a diminution of dopamine--hydroxylase activity (Ross, 1976), therefore functioning as a noradrenergic toxin

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These findings provide a novel perspective and potential targets for elucidating its pathophysiological mechanisms and developing innovative diagnostic and therapeutic strategies (103, 105)

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