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Administration of radio-labeled proteins, such as insulin-like growth factor-1 (IGF-1) and interferon-beta 1b (IFN-1b), into the rat nose leads to their distribution along trigeminal and olfactory nerve associated pathways and dissemination into both rostral and caudal regions of the rat brain within 3060 min, thus providing evidence of rapid brain access of CNS acting drugs through intranasal delivery [32, 33]

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These additional components, while benign in a cosmetic cream, could interact with biological systems in unpredictable ways when introduced into a research setting

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Engineered kidney tubules for modeling patient-specific diseases and drug discovery