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rare variants cause energy deficiency SLC52A3 and SLC52A2 riboflavin transporters

Vitamin B12 Benefits: An Inconspicuous Vitamin with a Mighty Effect While other vitamins, such as C, D and E, have recently received lots of attention, vitamin B12 is still a somewhat inconspicuous vitamin

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chronic liver disease and hepatitis may present with elevated levels Renal impairment : Reduced clearance can contribute to accumulation, though this is rarely clinically significant Solid tumours : Certain malignancies, particularly hepatocellular carcinoma and metastatic disease, may elevate B12 levels [3] Evidence suggests that unexplained markedly elevated B12 levels without supplementation may sometimes be associated with underlying disease

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Vitamin B12 deficiency may contribute to neurological symptoms such as numbness, tingling, reduced sensation, and peripheral neuropathy, as well as megaloblastic anemia caused by impaired red blood cell production