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The gut microbiota comprises autochthonous microbes (Autochthonous refers to indigenous or native microbial species that are typically well-adapted to a specific environment, such as the gut) residing on the colonic mucosa epithelium and allochthonous microbes (Allochthonous refers to microbial species that are not native to a particular environment but are introduced from external sources) transiently passing through the lumen with digesta (Schnabl and Brenner, 2014)