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On the contrary, microsomal GSTs, also known as MAPEG (membrane-associated proteins involved in eicosanoid and glutathione metabolism), are integral membrane proteins which are not evolutionary related to the other major classes

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Conclusion In conclusion, this review demonstrates that lactate and lactylation modifications, due to their involvement in critical brain metabolic pathways and their regulation of various gene transcription and protein functions, play a crucial regulatory role in the context of brain diseases

By supplying a direct, ready-to-use pool of Acetyl-CoA, ALCAR bypasses several rate-limiting steps in cellular metabolism