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Weight Loss Outcomes (72 weeks): 5 mg dose : 15.0% average body weight loss (34 lbs average) 10 mg dose : 19.5% average body weight loss (44 lbs average) 15 mg dose : 20.9% average body weight loss (48 lbs average) Placebo : 3.1% average body weight loss (7 lbs average) Clinically Meaningful Results: 91% of participants lost at least 5% of body weight (15 mg dose) 84% lost at least 10% of body weight 71% lost at least 15% of body weight 57% achieved 20% or greater weight loss SURMOUNT-2: Weight Loss in Diabetes Patients How Zepbound (tirzepatide) works for weight loss in patients with type 2 diabetes was evaluated in Tirzepatide once weekly for the treatment of obesity in people with type 2 diabetes (SURMOUNT-2) (Garvey et al., The Lancet , 2023), which enrolled 938 adults with type 2 diabetes and obesity or overweight over 72 weeks: 10 mg dose : 12.8% average weight loss 15 mg dose : 14.7% average weight loss Additional benefit: 2.1% reduction in HbA1c levels Understanding the Numbers A 20% body weight reduction for a 250-pound individual means losing approximately 50 pounds

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