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Science 275, 209213

The clinical phenotype suggests an important role for collagen III in either the synthesis or deposition of heterotypic fibrils containing largely collagen I, but remarkably, the precise mechanism of disease is still unknown

However, like other Khavinson peptides , Pinealon faces skepticism - most research conducted in Russia with limited Western replication, no FDA approval or large-scale international trials, mechanisms not fully elucidated despite decades of study, optimal dosing based on Russian protocols without rigorous dose-finding studies, and long-term safety data from clinical use rather than controlled trials

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