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Indeed, iron is a strong promoter of oxygen radical species that can drive the oxidation of proteins, lipid peroxidation and nucleic acid modifications [2]

J Biol Chem 1929;82:345-367

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Moreover, up to 61% of the Latin American and Caribbean population showed a reduced concentration of vitamin B12, which is caused by nutritional deficits affecting a large sector of the population, including vegetarians ( Additionally, HCys levels tend to increase with age both in males and females and may vary according to different habits, such as cigarette smoking, alcohol consumption, and sedentary lifestyle ( A reduction of HCys plasma levels has been linked to pregnancy ( Cardiovascular Effects of Hyperhomocysteinemia HHCys Effects in the Atherogenesis Many recent studies supported the theory of a correlation between increased levels of HCys and high blood pressure, both independent risk factors for cardiovascular disease and stroke (Figure 2)