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Recent advances in neuroimaging technology allowing for in vivo quantification of GSH levels in the brain have shown decreased GSH in patients with MS compared to healthy controls, with the degree of depletion correlating with disease severity and showing parallel longitudinal decline over time (Choi et al., 2018

The deletion of gshA resulted in the lack of GSH and its intermediates, and cells with deleted gshB gene still produced -glutamylcysteine, which is an intermediate of GSH biosynthesis that exhibits antioxidant properties [11]

Similarly, acalabrutinib (AP-196), a third-generation BTK inhibitor in combination with anti-PD-1 therapy in a Phase II trial (NCT02362048), displayed sustained and selective reduction in PMN-MDSCs while sparing M-MDSCs (107)

The authors declare no conflict of interest.

Even slight differences in the synthesis process of nanoparticles can lead to inconsistent results, affecting the sensors reliability, sensitivity, and reproducibility across different batches or over time

The incidence of alveolar/bronchiolar adenomas was significantly higher in treated mice of both sexes than in controls (NCI, 1978)