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Although SPME has been used to predict the toxicity or bioconcentration of hydrophobic organic contaminants in complex matrices, such as soil and sediment 36,37 , determining the ionizable compound content by SPME is difficult, and SPME cannot simulate the ion-trapping model

Dec 2017;83:173-182

It is most famous in the aesthetics world for its ability to stimulate collagen synthesis and promote skin regeneration, demonstrated in multiple human clinical trials

& Tsai, W

These differences likely reflect local tissue binding, lymphatic uptake, and first-pass metabolism variations between administration sites and species