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September 15, 2017

FIGURE 3 Lysine Glutarylation Non-enzymatic reactions: Similar to acetyl coenzyme A and succinyl coenzyme A, glutaryl-CoA can directly induce the non-enzymatic Kglu ( in vivo ( Enzymatic reaction: P300, a member of histone acetyltransferases (HATs), is a well-studied transcription co-activator ( in vitro , no acyltransferase could catalyze the transfer of malonyl, succinyl, or glutaryl to proteins in vivo ( Lysine Deglutarylation Sirtuins are a class of protein deacylases and/or ADP ribosyltransferases that depend on NAD + ( + binding and catalytic domains ( Kglu is a PTM regulated by SIRT5, which possesses potent desuccinylase, demalonylase, and deglutarylase activities ( + as a cofactor, which is inhibited by nicotinamide, a class III HDAC inhibitor ( Another study showed that SIRT7 catalyzed the hydrolysis of glutaryl peptides in the presence of nicotinamide adenine dinucleotide (NAD) and DNA in vitro and in cells ( in vivo

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