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Misoprostol, an FDA-approved prostaglandin analog, prevents NSAID-induced ulcers with a number needed to treat (NNT) of approximately 8 based on the MUCOSA trial 12

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There is a cumulative benefit during exposure, but this does not extend indefinitely, This month's Direct Line covers two subscriber questions

No data addresses cumulative effects from repeated annual cycles or potential delayed toxicity beyond one year

National regulations also vary

Reducing scar formation while maintaining healing efficiency requires influencing how collagen is deposited and organized during repair