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However, not all patients with severe cyanide poisoning given the sodium nitrite/sodium thiosulfate antidote combination have survived (Chen & Rose, 1952

In older patients, B12 deficiency can mimic early dementia, and correcting the deficiency sometimes produces noticeable improvement in cognitive function

Because they are naturally occurring sequences in the human body, they are generally well-tolerated with minimal documented toxicity

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[63] In August 2022, a bivalent version of the vaccine (Pfizer-BioNTech COVID-19 Vaccine, Bivalent) was authorized for use as a booster dose in individuals aged twelve and older in the US