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In contrast, CHAC1-driven GSH degradation reduces protein SSG, enhances transferrin receptor (TFRC)mediated iron uptake, and exacerbates ferroptosis, whereas hemoglobin SSG shields reactive cysteine residues from excessive oxidation 127,128

The panel of AdA and Asp performed well in identifying DILI patients with a high risk of chronicity at the early stage of the disease, which could help with early intervention in clinical practice

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The authors hypothesize that Nox5 activation may be dependent on post-translational modifications [32]

J Clin Invest 128:33413355 Robberecht W, Philips T (2013) The changing scene of amyotrophic lateral sclerosis

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