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We propose that chronic exposure to a particular suite of environmental and genetic factors elicits a trajectory of impaired mitochondrial biology that maximally impacts subsets of mitotypes abundant in the hippocampus, entorhinal cortex, and cerebral cortex, which eventually surfaces as the hallmark features of AD

Our system offers spatiotemporal control unachievable with systemic administration

The reprogramming of TAMCs correlates with increased expression of CD69, IFN-, granzyme B (GzmB), and Ki67 in T cells, while the expression of PD-1 is reduced

15 Children with CVS often accompany psychiatric disorders such as anxiety disorders or depression

H.PrattL.DenneS.GolichowskiA.et al (1996)