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While metformin has been demonstrated to improve mitochondrial respiration, it is worth noting that higher doses of metformin have been associated with a contrary effect, namely, reduced mitochondrial respiration

Certain groupssuch as older adults, vegetarians, individuals with gastrointestinal disorders, and those taking specific medications (e.g., metformin or proton pump inhibitors)may develop a B12 deficiency

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10.1186/s12882-018-1094-z Summary Keywords chronic kidney disease, cellular senescence, interaction, mechanism, therapy Citation Zhao J-L, Qiao X-H, Mao J-H, Liu F and Fu H-D (2022) The interaction between cellular senescence and chronic kidney disease as a therapeutic opportunity

doi: 10.1089/scd.2010.0093 45 LyCHLynchGSRyallJG

The fertilization rate (the number of 2PNs divided by the total number of MII oocytes), quality of obtained embryos, implantation rate (the number of intrauterine gestational sacs divided by transferred embryos), as well as clinical pregnancy rate (by detecting fetal heartbeats two weeks following the positive hCG) and ongoing pregnancy rate (a pregnancy documented by ultrasound over 20 gestational weeks that showed the presence of normal fetus)