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These are scars that are depressed, and can be grouped into the boxcar, icepick, or rolling categories, based on the shape of the scar indentation

4.1 Re-evaluating therapeutic approaches in AD For years, the amyloid cascade hypothesis has been the dominant framework guiding AD research

Second, central to the "iron-dependent" nature of ferroptosis, ferrous ions (Fe 2 ) in the labile iron pool are the key catalysts for the Fenton reaction, which generates highly reactive hydroxyl radicals

Less immune-cell infiltration into the postischemic area suggested either that Fer-1 directly inhibits leukocyte transmigration or that the local proinflammatory microenvironment was less chemoattractive, presumably by less damage-associated molecular pattern (DAMP) release due to less ferroptotic cell death

The dsRNA replicative intermediate is a potent pathogen-associated molecular pattern (PAMP) sensed by pattern recognition receptors (PRRs) in the cytoplasm (RIG-I-like receptors (RLRs)) and the endosome (Toll-like receptor 3 (TLR3))

Neyra et al., 2023