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N-terminal acetylation, the Nle 4 substitution (methionine replaced by norleucine, oxidation-resistant), the D-Phe 7 substitution (stereochemical inversion resistant to proteolysis) and lactam cyclization are the four pharmacochemical innovations that transform alpha-MSH's 2-5 minute half-life into a multi-hour half-life

43 Hypoxia induces the transcriptional factor sterol regulatory-element binding protein-1 through phosphorylation of protein kinase B and activation of HIF1, leading to upregulation of fatty acid synthase

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This fusion protein enhances the paracrine role of MSCs