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Activated pSHP1 (a phosphatase) then dephosphorylates and inactivates pSrc, inhibiting the ETC

To differentiate between the potential involvement of these two consequences in H 2 O 2 -induced sensitization to TNF hepatotoxicity, we first exposed HepG2 cells to (BSO), a potent inhibitor of gamma-glutamylcysteine synthetase, the rate-limiting enzyme in the glutathione synthesis pathway (Fig

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