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J Biol Chem (2016) 291(27):1427484

doi: 10.1016/j.ebiom.2020.102913

Rogaeva E, Meng Y, Lee JH, Gu Y, Kawarai T, Zou F, Katayama T, Baldwin CT, Cheng R, Hasegawa H, et al

Abnormalities in histone deacetylases (HDACs) can drive immune dysregulation in PAH by downregulating Foxp3 + Tregs

Preventive measures, such as maintaining proper hygiene, staying hydrated, and managing underlying medical conditions, can help reduce the risk of developing abnormal urine appearance