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This phenomenon is induced by activated pattern recognition receptors (PRRs, e.g., toll-like receptor 9 [TLR9] and nod-like receptor pyrin domain containing 3 [NLRP3]) sensing damage-associated molecular patterns (DAMPs) (Rodrigues et al., 2015)

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the compositions comprise from about 0.01 milligrams (mg) to about 100 mg of cannabinoid, about 0.5 mg to about 100 mg cofactor or precursor thereof, and about 0.1 mg and 100 mg antioxidant per milliliter of composition, including all ranges and subranges therebetween