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NOX1 in PACs and NOX2 in neutrophils generate superoxide anion (O 2 - ), contributing to oxidative tissue injury and inflammatory amplification ( NADPH occupies a central position at the intersection of mitochondrial metabolism, antioxidant defense, and redox signaling

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However, many of these trials were limited by small sample sizes, short intervention durations, heterogeneous dosing protocols, and the potential for placebo effects, which constrain direct clinical extrapolation

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