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In a murine model of hepatocellular carcinoma, the hypermethylation of CXCL9 and CXCL10 promoter leads to reduced expression of these chemokines

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The mechanics of the carnitine shuttle are precise and highly regulated

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Therefore, tumor therapy should not only focus on tumor cells but also focus on the remodeling of TME

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Various authors have shown that serum ammonia concentrations directly correlate with the dose or serum concentrations of VPA, and inversely with serum concentrations of carnitine [22, 38, 39]

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