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In addition, no covariate (in particular dosage) was incorporated into the E max model, showing there was no significant dose-dependence from l-carnitine efficacy on BMI in T2DM patients

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October 2002;16(12):15841594

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the (R)-4-chloro-3-hydroxy butyric acid alkyl ester is reacted with trimethylamine, and the reaction product is treated with hydrochloric acid and passed through an anion-exchange resin column to thereby prepare L-carnitine

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