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They may interact with medication or cause mild side effects

Metabolism and functions

10.1371/journal.pone.0076474 PLoS One 107 QuQ.ZengF.LiuX.WangQ

The average of seven RCTs showed a decrease of 3.54 mg/dL (9 nmol/L).[ref] While a small reduction, it may be significant when combined with other interventions.[ref] Related article: CoQ10: background science, mitochondrial energy, and genetic variants Niacin: Vitamin B3 niacin has been used for decades to lower the risk of heart disease