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DDR pathway activation phosphorylates and activates p53, which subsequently induces the expression of p21 23

[DOI] [PubMed] [Google Scholar] 29.Mencherini T., Picerno P., Festa M., Russo P., Capasso A., Aquino R

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The identification of breast cancer susceptibility genes BRCA1/2 , whose proteins are involved in DNA repair through homologous recombination, 106,107 has shed light on some mechanisms behind sporadic and hereditary breast cancers

Most importantly, testing the above hypothesis requires an experimental model for the alteration of methylglyoxal- dependent GSH metabolism by cellular methylglyoxal accu- mulation