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can occur at any age ,rare 90% of patients Serum creatine kinase (CK) level- mildly elevated or normal Muscle biopsy is not usually required, normal in early stage, later shows denervation atrophy Sural nerve biopsy tissue shows segmental demyelination, focal inflammation, and wallerian degeneration Variants of GBS Acute inflammatory demyelinating polyradiculoneuropathy (AIDP) Most common variant in Europe and USA, most studied type Is triggered by antecedent viral or bacterial infection Electrophysiologic findings demonstrate demyelination

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The Deubiquitylase OTUB1 mediates ferroptosis via stabilization of SLC7A11