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Abstract Chronic hypoxia leads to irreversible cognitive impairment, primarily due to hippocampal neurodegeneration, for which the underlying mechanism remains poorly understood

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J Pharmacol Sci 137:170176

Schappo, H., Giry, K., Salmoria, G., Damia, C

1132 (eds Kaminski, H

In SH-SY5Y cells, valerian has been shown to inhibit rotenone-induced cell death ( Drosophila melanogaster , as evidenced by the normalization of superoxide dismutases-SOD and catalase mRNA expression, implying that valerians effects are, at least in part, due to the plants antioxidant properties due to its phenolic and flavonoid constituents (Sudati et al., 2013)