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and (iii) EFD expression is upregulated in samples where the GSH:hGSH ratio changed and the GSH content reached levels twofold higher than those of hGSH (WT + 0.1 mM GSH and sym33-3 + 0.1 mM GSH treatments), but was downregulated in the cases where hGSH content was higher than that of GSH ( sym40-1 + 0.1 mM GSH treatment) (Supplementary Table 6)