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Hyperuricemia: A key contributor to endothelial dysfunction in cardiovascular diseases

In non-enzymatic processes, the H 2 O 2 combines with Fe 2+ (e.g., ferritin protein) or Cu 2+ (e.g., ceruplasmin protein) ions in the Fenton reaction, where it accepts an electron from metal ions to form highly reactive (t 1/2 = 10 9 s) HO radical and HO + ion and thus are highly reactivity in the mitochondrial matrix [16]

It is estimated that the burden will double over the next two decades (Checkoway et al

doi: 10.1210/en.20161472 152 LuqueRMHuangZHShahBMazzoneTKinemanRD