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The effects of drugs on cell proliferation were determined by comparing the absorbance of cells grown in the presence of drugs to solvent control without added drugs (100% cell survival)

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The neurobiological mechanisms underlying the observed therapeutic effects involve regulating monoaminergic neurotransmission, alleviating oxidative stress, maintaining mitochondrial function, suppressing neuroinflammation, and modulating the KEAP1/Nrf2 pathway, which regulates redox homeostasis and mitochondrial function and plays a crucial role in regulating neuroinflammation