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Among the global metabolic alterations identified, several pathways were found to converge on glycolysis and glucose metabolism, which represent central hubs in cellular energy homeostasis and are strongly implicated in ALS pathophysiology

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Stringer, M.L

Since fermented foods can be used as a probiotic carrier and contain health-promoting components ( Gut Microbiota, Immune System and Rheumatoid Arthritis It is now well established that more than 100 trillion microorganisms, primarily bacteria, colonize the human oral-gastrointestinal tract, most residing in the distal intestine ( The clinical picture of RA results from a complex interaction between various factors, including autoantibodies and signal transduction pathways of the innate and adaptive immune system ( To support the hypothesis that changes in GM composition play a significant role in the onset and progression of RA (Figure 1 summarizes the pathophysiology of RA and the proposed mechanisms whereby GM could participate in triggering autoimmunity and systemic inflammation in susceptible individuals

In: Kaneko JJ (ed) Clinical biochemistry of domestic animals, third edn