The main roles of the complement activation are (1) opsonization of microbes and promoting phagocytosis, (2) triggering of inflammation process after diffusion of complement components away from the site of activation, (3) elimination of large immune complexes from the blood, and (4) membrane rupture of foreign cells
This pharmacokinetic behavior supports the titration-based dosing strategies used in the ATTAIN and ACHIEVE trials, where the starting dose is low and gradually increased over several weeks to the target maintenance dose
However, it is important to note that not all symptoms resolve completely , especially if neurological damage was severe or prolonged before treatment commenced
Some sources cite 30 days, but 28 is the more conservative and widely accepted timeframe
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This suggests that continued use of SSRIs may benefit the sleep quality of some individuals in clinical practice
