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2 Key regulatory mechanisms of EMT 2.1 Central role of TGF- superfamily signaling As a pleiotropic cytokine, transforming growth factor- (TGF-) exerts pivotal regulatory functions in pulmonary fibrosis via both Smad-dependent and Smad-independent pathways, driving epithelialmesenchymal transition (EMT) and promoting airway inflammation and remodeling ( The TGF-/Smad cascade also contributes to airway fibrosis through induction of amphiregulin (AREG), which activates EGFR signaling to enhance fibroblast proliferation and myofibroblast conversion

Some of our therapies are available without blood work testing

[Google Scholar] 95.Xiao S., De Zhang Z., Lu H., Jiang S., Liu H., Wang G., Xu G., Zhang Z., Lin G., Wang G

We included the DC Function measure under the LTCH QRP on the publicly available MUC List for December 1, 2022

doi: 10.1021/acsomega.8b00841

All experiments were performed on at least three independent occasions