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This key role of antioxidants on microbiota probably extends beyond the digestive tract, as the beneficial effect of butyrate has been suggested for other human microbial ecosystems, such as the skin 46 , the gut-brain axis 47 and atopic diseases 48

doi: 10.3389/fcell.2021.732820 45 MahajanNAroraPSandhirR

Pollution, smoking, lack of sleep, poor diet, and UV exposure all increase oxidative stress

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1 2 "Neurotransmitter receptors in the life and death of oligodendrocytes"

We also detected a significant drop in total GSH in ADH5 cells, which might indicate that the active efflux of HSMGSH could contribute to a drop in the net cellular GSH thus also affecting cellular redox homeostasis (Fig