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The only formal clinical dose in the human record is the postoperative-ileus trial, which used 0.03 mg/kg intravenously twice daily for up to seven days

Therefore, it seems that despite the presence of Mn in the Mn-dependent SOD, this trace metal alone does not play a major role in the disease

It has been shown to upregulate growth factors such as VEGF and enhance collagen formation in cultured cells

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