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In vitro , insulin resistance was induced in HepG2 cells by glucosamine administration

Preclinical research has revealed a broad spectrum of biological activities, including gastric cytoprotection, modulation of the nitric oxide (NO) pathway, and interaction with the dopaminergic system

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The investigators reported that NNMT knockdown produced protection from diet-induced obesity and increased adipocyte energy expenditure, establishing the genetic precedent for the 5-Amino-1MQ pharmacological program

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