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These include lung injury and fibrosis (356, 357, 520)

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According to recent research, p110 disruption slows down the onset and development of CRPC, however, p110 inhibition has no effect on PTEN-null CRPC [43]

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In the case of troglitazone (an antidiabetic drug, voluntarily withdrawn from the market by the licence holder in 2000), it was reported that 1.95% of patients treated with troglitazone in clinical trials developed eleva-tions of aminotransferases that were greater than three times the upper limit of normal