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By modifying the secretion system through domain swapping and altering the dsbA and pelB signal peptides, the researchers achieved a 3.5-fold increase in the yield of secreted ATH35L (Han et al., 2021)

Gene and protein expression of P-glycoprotein, MRP1, MRP2, and CYP3A4 in the small and large human intestine

Aging epithelial cells can produce a variety of pro-inflammatory and pro-fibrotic mediators, such as Interleukin 6 (IL-6), IL-1 and TGF-, which are part of the senescence-associated secretory phenotype (SASP) (Merkt et al., 2020)

First, they suggest that AOD-9604 can be used for extended periods without loss of efficacy due to antibody neutralization