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Although cholesterol-deficient diets, such as veganism or other plant-based, low-cholesterol regimens, are naturally devoid of dietary cholesterol and are typically associated with lower serum low-density lipoprotein cholesterol (LDL-C) levels, this reduction is compensated mainly by an upregulation of endogenous cholesterol synthesis, primarily through increased activity of hepatic 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, the rate-limiting enzyme in the mevalonate pathway

Conclusion The MAPK-ERK1/2 signaling pathway plays a major role in the inflammatory and remodeling phases of asthma pathophysiology

[0417] Like PE, diphtheria toxin (DT) kills cells by ADP-ribosylating elongation factor 2 thereby inhibiting protein synthesis

doi: 10.1245/s10434-018-6662-8 133 MontfortAPearceOManiatiEVincentBGBixbyLBohmSet al

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