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The authors suggest that MgH 2 , by modulating TRPM2, suppresses NLRP3 inflammasome formation and reduces microglial activation, alleviating pain [115]

Importantly, oxidative damage caused by the production of ROS has been linked to the etiology of different types of human cancer [23, 36]

Fluconazole combined with 5-flucytosine is emerging as an important approach to the treatment of cryptococcosis because it avoids the toxicities associated with amphotericin B 28

PLos One (2014) 9:e102798

Scientific reports 7 , 3542, (2017)

While AOPs can conceptually link a molecular initiating event to an adverse outcome in an individual, predicting how this translates to population-level effects (e.g., reduced population viability) or community-level impacts (e.g., altered species composition or impaired ecosystem functions like primary productivity) requires a new generation of integrated ecological models that are still in their infancy for nanomaterials