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Engineered histidine-rich peptides enhance endosomal escape for antibody-targeted intracellular delivery of functional proteins

doi: 10.1128/IAI.01227-12 78 HartzenS

Honest answer: it depends on the molecule and the dose

The aim of this review is to summarize the knowledge on synthetic AT

To date, the standard treatment for high-grade gliomas (HGGs) consists of surgical tumor resection followed by fractionated radiotherapy and chemotherapy with alkylating agents, such as temozolomide (TMZ) 93,94,95 , or with molecular targeted drugs (for recurrent tumors), such as bevacizumab (BEV) (an antiangiogenic drug) 96,97,98,99 and irinotecan (a DNA topoisomerase I inhibitor) 97,100