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50 Furthermore, functional MRI (fMRI) indicates increased gray matter volume but reduced white matter volume in CMS patients, alongside abnormal spontaneous activities in multiple brain regions

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This allows it to reach tissues that wouldnt normally get much ALA which may explain why higher supplemental doses (like 600mg) can affect nerve health, blood sugar, and oxidative stress in ways your bodys natural supply cant.12 Once you take ALA as a supplement, several factors affect how well your body absorbs and uses it