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Description

Significant degeneration and necrosis were observed in the neurons of the rats in the DM group, accompanied by pronounced hyperemia in the parenchyma and meningeal arteries

This inhibition translated to reduced secretion of CXCL8 and CCL2 by RA synovial fibroblasts stimulated with TNF alone or the combination of TNF, IL-1 and a TLR3 agonist

It does not exist naturally and is only made artificially

These are described as community-reported tolerability observations, not a controlled finding but they're consistent with how topical actives behave generally