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This phenomenon appears to be multifactorial, driven by increased awareness of androgen deficiency syndromes, the expanding off-label prescription of testosterone preparations, and the widespread non-medical use of anabolicandrogenic steroids (AAS) to enhance physical performance and appearance

Funding This is an investigator-initiated study, and no grant funding was obtained

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91,92,93 For example, in the BALF of patients receiving lung transplants, different families of Anelloviridae formed nearly 70% of the lung virome, and they were considered pathogenic

Exp Neurol 203(2):51220, PMID: 17049515 Shen H, Liu Z (2006) JNK signaling pathway is a key modulator in cell death mediated by reactive oxygen and nitrogen species

In addition, nobiletin treatment restored the reduced expression of some ferroptosis-related factors, including GPX4, SLC7A11, and TFR1 [248]