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Glutathione reductase is essential for maintaining adequate levels of reduced glutathione, and its suppression limits the capacity of cells to neutralize reactive oxygen species, thereby amplifying oxidative stress

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This interaction produces a hydroxylated 2-pyridine metabolite that effectively inhibits xanthine oxidase, a critical enzyme in uric acid metabolism

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Maps were deposited at Electron Microscopy Data Bank with accession EMD-42884, B-factor sharpened map, EMD-41018 DeepEmhanced map, EMD-41090, composite map, all with accompanying raw half maps