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In addition to liquid biopsy, tumor tissue biopsy-guided precision medicine in the multi-omics era also enables the development of novel metabolism-based therapeutic strategies, offering new opportunities to overcome treatment resistance in PDAC [132]

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Longevity and Anti-aging : NAD+ plays a crucial role in maintaining mitochondrial health, reducing oxidative stress, and promoting DNA repairessential factors for slowing aging

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Antioxidant strategies must focus not just on scavenging ROS, but on restoring upstream redox sensing, mitochondrial biogenesis, and Nrf2 signaling

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Front Pediatr 10:988601

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Acknowledgements This study was funded by National Institutes of Health P50MH106438 and R01MH059883 grants awarded to C.S.C

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doi:10.1111/j.1600-0536.2012.02026.x

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