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Along with this damage, there is a reduction in mitophagy, the process of removing damaged mitochondria, leading to accumulation of damaged mitochondria further contributing to systemic inflammation

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The inhibitor effect is concentration dependent

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10.1016/j.cmet.2006.02.002 76 KobayashiH.LiuQ.BinnsT

The same lack of increased basal oxidative stress was recapitulated with shRNA depletion of ATM (Fig