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The failure of antioxidant systems, particularly glutathione peroxidase 4 (GPX4), which reduces lipid hydroperoxides to non-toxic lipid alcohols, leads to the collapse of membrane integrity and ferroptotic cell death ( A central regulator of ferroptosis and oxidative stress responses is nuclear factor erythroid 2-related factor 2 (Nrf2), a transcription factor that controls the expression of a wide array of antioxidant and cytoprotective genes

Coronary vasospasm that results in significant obstruction is the basis for Prinzmetal's variant angina

Vitamin B12 can decrease blood homocysteine, a type of amino acid that is associated with an increased risk of heart disease

As of this writing, three gene therapy clinical studies employing various lentiviral vectors have allegedly successfully treated a small number of patients with SCD

2008), CBD could eventually be repurposed as an antibacterial agent

Use of diuretics in patients with hypertension